Abstract
A cytopathic 'stealth' virus was cultured from the cerebrospinal fluid of a patient with a bipolar psychotic disorder who developed a severe encephalopathy leading to a vegetative state. DNA sequencing of a polymerase chain reaction-amplified product from infected cultures has identified the virus as an African green monkey simian cytomegalovirus (SCMV)-related stealth virus. The virus is similar to the SCMV-related stealth virus isolated from a patient with chronic fatigue syndrome. The findings support the concepts that stealth viruses can account for a spectrum of dysfunctional brain diseases and that some of these viruses may have arisen from live polio viral vaccines.
MeSH terms
-
Adult
-
Animals
-
Base Sequence
-
Bipolar Disorder / cerebrospinal fluid
-
Bipolar Disorder / diagnosis
-
Bipolar Disorder / etiology
-
Bipolar Disorder / virology*
-
Cells, Cultured / virology
-
Cerebrospinal Fluid / virology
-
Chlorocebus aethiops / virology*
-
Cytomegalovirus / genetics
-
Cytomegalovirus / immunology
-
Cytomegalovirus / isolation & purification*
-
Cytomegalovirus Infections / cerebrospinal fluid
-
Cytomegalovirus Infections / complications
-
Cytomegalovirus Infections / diagnosis
-
Cytomegalovirus Infections / transmission
-
Cytomegalovirus Infections / virology*
-
Cytopathogenic Effect, Viral
-
DNA, Viral / genetics
-
DNA, Viral / isolation & purification
-
Diagnosis, Differential
-
Drug Contamination
-
Encephalitis, Viral / cerebrospinal fluid
-
Encephalitis, Viral / complications
-
Encephalitis, Viral / diagnosis
-
Encephalitis, Viral / virology*
-
Epilepsy, Generalized / diagnosis
-
Epilepsy, Generalized / etiology
-
Female
-
Fibroblasts / virology
-
Hallucinations / diagnosis
-
Hallucinations / etiology
-
Humans
-
Macaca mulatta
-
Molecular Sequence Data
-
Persistent Vegetative State / etiology
-
Poliovirus Vaccine, Oral / adverse effects
-
Schizophrenia / diagnosis
-
Sequence Alignment
-
Species Specificity
-
Virus Cultivation
Substances
-
DNA, Viral
-
Poliovirus Vaccine, Oral