Allergy development and macromolecular absorption in infants with different feeding regimens during the first three days of life. A three-year prospective follow-up

Acta Paediatr. 1996 Sep;85(9):1047-52. doi: 10.1111/j.1651-2227.1996.tb14215.x.


A group of 129 infants were randomly assigned at birth to one of three feeding regimens: human milk (HM), cow's milk formula (CMF) or a casein hydrolysate formula (CHF) during the first 3 days of life. Blood samples were taken on at 4 days and at 2, 4, 8, 12 and 24 months of age. Macromolecular absorption was analysed by measuring the serum concentration of human alpha-lactalbumin (S-alpha-LA) with a competitive radioimmunoassay (RIA). Total serum IgE was measured by RIA. A family history of allergy correlated to the proportion of infants with allergic symptoms both at 24 and 36 months of age (p = 0.03 and p = 0.04 respectively). In none of the three groups did correlation exist between the duration of breastfeeding and serum alpha-LA, serum IgE, family history of allergy, frequency of allergic symptoms and proportion of infants with infections.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Caseins
  • Female
  • Follow-Up Studies
  • Humans
  • Hypersensitivity* / epidemiology
  • Immunoglobulin E / blood
  • Infant Food*
  • Infant, Newborn
  • Lactalbumin / blood
  • Male
  • Milk
  • Milk, Human*
  • Prospective Studies
  • Protein Hydrolysates
  • Radioimmunoassay
  • Risk Factors


  • Caseins
  • Protein Hydrolysates
  • trypticase-soy broth
  • Immunoglobulin E
  • Lactalbumin