Oral IgA-IgG treatment of chronic non-specific diarrhoea in infants and children

Acta Paediatr. 1996 Sep;85(9):1126-8. doi: 10.1111/j.1651-2227.1996.tb14231.x.

Abstract

The effect of orally administered immunoglobulin (IgAbulin) on chronic non-specific diarrhoea of infancy was studied in seven children, median age 26 (21-36) months and duration of diarrhoea 32 (18-84) weeks. Routine laboratory tests for malabsorption and small bowel biopsies were taken in all children before and after 3 weeks of IgAbulin treatment. The biopsy specimens were analysed with regard to histopathology, electronmicroscopy, immunohistochemistry and microbiology. The number of stools decreased from a median of 4.0 (3.0-5.0) to 1.5 (1.0 3.5) (p < 0.05) stools per day over the study period.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Child, Preschool
  • Chronic Disease
  • Diarrhea, Infantile / immunology
  • Diarrhea, Infantile / therapy*
  • Feces / chemistry
  • Humans
  • Immunoglobulin A / administration & dosage*
  • Immunoglobulin A / analysis
  • Immunoglobulin G / administration & dosage*
  • Immunoglobulin G / analysis
  • Infant
  • Intestinal Absorption
  • Intestines / microbiology
  • Intestines / pathology
  • Prospective Studies

Substances

  • Immunoglobulin A
  • Immunoglobulin G