Enzymatic Synthesis of Two Isoxazolylalanine Isomers by Cysteine Synthases in Lathyrus Species

Biol Pharm Bull. 1996 Sep;19(9):1214-5. doi: 10.1248/bpb.19.1214.

Abstract

Two isoxazolylalanine isomers, beta-(isoxazolin-5-on-2-yl)-L-alanine (BIA, 1) and beta-(isoxazolin-5-on-4-yl)-L- alanine (TAN-950A, 2) were confirmed to be derived from O-acetyl-L-serine (OAS) and isoxazolin-5-one by cysteine synthases (CSases) with a different ratio in different plant parts. Some properties of this enzyme in the biosynthesis of both isomers are described.

MeSH terms

  • Alanine / analogs & derivatives*
  • Alanine / metabolism
  • Chemical Phenomena
  • Chemistry, Physical
  • Cysteine Synthase / metabolism*
  • Fabaceae / enzymology*
  • Hydrogen-Ion Concentration
  • Isomerism
  • Isoxazoles / metabolism*
  • Kinetics
  • Plants, Medicinal*
  • Spectrophotometry, Ultraviolet

Substances

  • Isoxazoles
  • beta-(isoxazolin-5-on-4-yl)alanine
  • (isoxazolin-5-on-2-yl)alanine
  • Cysteine Synthase
  • Alanine