Inhibition of human cytochrome P450-3A isoforms by fluoxetine and norfluoxetine: in vitro and in vivo studies

J Clin Pharmacol. 1996 Sep;36(9):792-8. doi: 10.1002/j.1552-4604.1996.tb04252.x.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Aryl Hydrocarbon Hydroxylases*
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 Enzyme Inhibitors*
  • Drug Interactions
  • Fluoxetine / analogs & derivatives*
  • Fluoxetine / pharmacology*
  • Humans
  • Isoenzymes / antagonists & inhibitors*
  • Oxidoreductases, N-Demethylating / antagonists & inhibitors*
  • Pharmacokinetics
  • Selective Serotonin Reuptake Inhibitors / pharmacology*

Substances

  • Cytochrome P-450 Enzyme Inhibitors
  • Isoenzymes
  • Serotonin Uptake Inhibitors
  • Fluoxetine
  • Aryl Hydrocarbon Hydroxylases
  • Cytochrome P-450 CYP3A
  • Oxidoreductases, N-Demethylating
  • norfluoxetine