Growth of Chlamydia pneumoniae induces cytokine production and expression of CD14 in a human monocytic cell line

Infect Immun. 1996 Nov;64(11):4872-5. doi: 10.1128/iai.64.11.4872-4875.1996.

Abstract

Chlamydia pneumoniae was able to survive and to multiply in the human monocytic cell line Mono Mac 6. Growth of C. pneumoniae induced production of tumor necrosis factor alpha, interleukin 1beta, and interleukin 6, as well as up-regulation of the CD14 molecule in a time-dependent manner. Infection of monocytic cells and a proinflammatory cytokine response may be important in C. pneumoniae pathogenesis.

MeSH terms

  • Cell Line
  • Chlamydophila pneumoniae / growth & development*
  • Cytokines / biosynthesis*
  • Humans
  • Interleukin-1 / biosynthesis
  • Interleukin-6 / biosynthesis
  • Lipopolysaccharide Receptors / biosynthesis*
  • Microscopy, Electron
  • Monocytes / immunology
  • Monocytes / microbiology*
  • Tumor Necrosis Factor-alpha / biosynthesis
  • Up-Regulation

Substances

  • Cytokines
  • Interleukin-1
  • Interleukin-6
  • Lipopolysaccharide Receptors
  • Tumor Necrosis Factor-alpha