Synaptogenesis and dendritic growth in the cortex opposite unilateral sensorimotor cortex damage in adult rats: a quantitative electron microscopic examination

Brain Res. 1996 Sep 9;733(1):142-8. doi: 10.1016/0006-8993(96)00792-5.


Unilateral lesions of the forelimb area of the sensorimotor cortex in adult rats resulted in time-dependent increases in the number of synapses per neuron and the volume and membrane surface area of dendritic processes per neuron within layer V of the contralateral motor cortex in comparison to sham-operated rats. Based on previous findings of a behavioral relationship with increased dendritic arborization, these changes may be related to lesion-induced compensatory changes in the use of the non-impaired (ipsilateral to the lesion) forelimb.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age Factors
  • Animals
  • Conditioning, Psychological / physiology
  • Dendrites / physiology*
  • Dendrites / ultrastructure
  • Forelimb / innervation
  • Male
  • Microscopy, Electron
  • Microtomy
  • Motor Cortex / pathology*
  • Neuronal Plasticity / physiology
  • Neurons / physiology
  • Neurons / ultrastructure
  • Rats
  • Rats, Inbred Strains
  • Somatosensory Cortex / pathology*
  • Synapses / physiology*
  • Synapses / ultrastructure