Fast 3D functional magnetic resonance imaging at 1.5 T with spiral acquisition

Magn Reson Med. 1996 Oct;36(4):620-6. doi: 10.1002/mrm.1910360418.


A new method to perform rapid 3D fMRI in human brain is introduced and evaluated in normal subjects, on a standard clinical scanner at 1.5 Tesla. The method combines a highly stable gradient echo technique with a spiral scan method, to detect brain activation related changes in blood oxygenation with high sensitivity. A motor activation paradigm with a duration of less than 5 min, performed on 10 subjects, consistently showed significant changes in signal intensity in the area of the motor cortex. In all subjects, these changes survived high statistical thresholds.

MeSH terms

  • Brain / pathology*
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Motor Cortex / pathology