Clozapine-induced cognitive dysfunction in mice

Methods Find Exp Clin Pharmacol. Jul-Aug 1996;18(6):367-72.

Abstract

The atypical antipsychotic clozapine was examined for its ability to interrupt cognitive functions in mice on passive avoidance paradigm and elevated plus maze. The posttraining intraperitoneal injection of clozapine (0.1-7.5 mg/kg) induced dysfunction in acquisition as well as retrieval, which was reversed by physostigmine (0.05 mg/kg). Clozapine showed dose-related effects on scopolamine-induced cognitive dysfunction, with higher doses having no significant effect and lower doses reversing the dysfunction. These results are explained on the basis of clozapine's effects on central cholinergic receptors.

MeSH terms

  • Animals
  • Antipsychotic Agents / administration & dosage
  • Antipsychotic Agents / toxicity*
  • Avoidance Learning / drug effects*
  • Clozapine / administration & dosage
  • Clozapine / toxicity*
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Drug Synergism
  • Electric Stimulation
  • Injections, Intraperitoneal
  • Maze Learning / drug effects*
  • Mice
  • Muscarinic Antagonists / administration & dosage
  • Muscarinic Antagonists / toxicity
  • Scopolamine / administration & dosage
  • Scopolamine / toxicity

Substances

  • Antipsychotic Agents
  • Muscarinic Antagonists
  • Scopolamine
  • Clozapine