Functional Diversity of Helper T Lymphocytes

Nature. 1996 Oct 31;383(6603):787-93. doi: 10.1038/383787a0.

Abstract

The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a framework for understanding the heterogeneity of normal and pathological immune responses. Defining the cellular and molecular mechanisms of helper-T-cell differentiation should lead to rational strategies for manipulating immune responses for prophylaxis and therapy.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmunity / immunology
  • Cell Differentiation / genetics
  • Cytokines / biosynthesis
  • Humans
  • Hypersensitivity / immunology
  • Infections / immunology
  • Self Tolerance / immunology
  • T-Lymphocyte Subsets / cytology
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocytes, Helper-Inducer / cytology
  • T-Lymphocytes, Helper-Inducer / immunology*

Substances

  • Cytokines