Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1996 Oct;17(4):707-18.
doi: 10.1016/s0896-6273(00)80202-0.

Mutations in a Cyclic Nucleotide-Gated Channel Lead to Abnormal Thermosensation and Chemosensation in C. Elegans

Affiliations
Free article
Comparative Study

Mutations in a Cyclic Nucleotide-Gated Channel Lead to Abnormal Thermosensation and Chemosensation in C. Elegans

H Komatsu et al. Neuron. .
Free article

Abstract

The C. elegans tax-4 mutants are abnormal in multiple sensory behaviors: they fail to respond to temperature or to water-soluble or volatile chemical attractants. We show that the predicted tax-4 gene product is highly homologous to vertebrate cyclic nucleotide-gated channels. Tax-4 protein expressed in cultured cells functions as a cyclic nucleotide-gated channel. The green fluorescent protein (GFP)-tagged functional Tax-4 protein is expressed in thermosensory, gustatory, and olfactory neurons mediating all the sensory behaviors affected by the tax-4 mutations. The Tax-4::GFP fusion is partly localized at the sensory endings of these neurons. The results suggest that a cyclic nucleotide-gated channel is required for thermosensation and chemosensation and that cGMP is an important intracellular messenger in C. elegans sensory transduction.

Similar articles

See all similar articles

Cited by 162 articles

See all "Cited by" articles

Publication types

MeSH terms

Associated data

LinkOut - more resources

Feedback