Midlife is a time of heightened reevaluation and reorientation during which individuals are faced with potentially stressful changes and turning points. Ego-resiliency (ER) is proposed to be a powerful personality resource that enables individuals to adaptively negotiate the challenges of this period. Through examination of data from 2 longitudinal samples of women (N = 208), Study 1 examined whether observer-based and self-reported ER assessed at the beginning of midlife (at age 43) can predict life adjustments of specific relevance to this period assessed in late middle age (ages 52 and 48). In Study 2 age 43 ER was used to predict directional changes in central life adjustments and feelings about life over this same period (between ages 43 and 52). Predictions across samples, across measures of ER, or both were confirmed by replicated findings.