Kartagener's syndrome: clinical presentation and cardiosurgical aspects

Ann Thorac Surg. 1996 Nov;62(5):1474-9. doi: 10.1016/0003-4975(96)00493-6.


Background: Long-term observations in patients with Kartagener's syndrome (situs inversus, bronchiectasis, and sinusitis) are rare. The role of additional cardiac malformations and their surgical repair is not well known.

Methods: Nine patients (5 female and 4 male) with Kartagener's syndrome were identified and followed. Four patients had associated cardiac anomalies; 4 underwent total surgical repair at the ages of 4 (2 patients), 7, and 34 years.

Results: The postoperative period was uneventful, and these 4 patients are doing well 7 months and 2, 9, and 19 years after repair. The other patients are being treated with conservative therapy and are in relatively good condition.

Conclusions: This disease can be temporarily benign when treated with antibiotics and physiotherapy. Associated cardiac anomalies seem to be quite common, and such patients need careful cardiologic follow-up. Surgical intervention can be safely performed in patients suffering from Kartagener's syndrome associated with a congenital cardiac malformation and produces good long-term results. Bilateral lung transplantation seems to be the therapy of choice in patients with respiratory insufficiency but without concomitant cardiac anomalies.

Publication types

  • Case Reports

MeSH terms

  • Aftercare
  • Cardiac Surgical Procedures / methods
  • Child
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Infant, Newborn
  • Kartagener Syndrome / diagnosis
  • Kartagener Syndrome / genetics
  • Kartagener Syndrome / surgery*
  • Lung Transplantation
  • Male
  • Treatment Outcome