Isolation, characterization and chromosomal assignment of the human WNT7A gene

Cytogenet Cell Genet. 1996;74(1-2):149-52. doi: 10.1159/000134404.


The Wnt genes compose a large gene family encoding a group of secreted signaling molecules that have been implicated in oncogenesis and a number of developmental processes. We have isolated a full-length human cDNA clone that we consider to be a novel member of the Wnt gene family. The gene (WNT7A) encodes a deduced 349-amino-acid peptide with 98% identity in amino acid sequence to murine Wnt7a. Expression of this gene is restricted to certain tissues: placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain. Furthermore, we have isolated a genomic clone of WNT7A and mapped it to chromosome 3p25 by fluorescent in situ hybridization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Blotting, Northern
  • Chromosome Mapping*
  • Chromosomes, Human, Pair 3*
  • Cloning, Molecular
  • DNA, Complementary / genetics
  • Female
  • Gene Expression / genetics
  • Humans
  • In Situ Hybridization, Fluorescence
  • Molecular Sequence Data
  • Proteins / genetics*
  • Proto-Oncogene Proteins*
  • Wnt Proteins


  • DNA, Complementary
  • Proteins
  • Proto-Oncogene Proteins
  • WNT7A protein, human
  • Wnt Proteins

Associated data

  • GENBANK/D83175