HLA antigens in polymyalgia rheumatica in northern Sweden

Clin Rheumatol. 1996 Sep;15(5):486-90. doi: 10.1007/BF02229647.


The HLA-A, B and DR antigens were analyzed with serological methods in 75 patients with polymyalgia rheumatica (PMR). In PMR patients the frequency of the HLA-DR4 antigen was significantly higher (62.1%) compared to blood donors (40%), p < 0.05, but did not differ from patients with seropositive rheumatoid arthritis (RA) from the same area (63.1%). In contrast, the frequency of HLA-B27 in the PMR patients (9.3%) was significantly lower compared to RA (27.2%), p < 0.01, but did not differ from blood donors (16.9%). There was no association between DR4 and disease affliction or severity in PMR. The increased frequency of HLA-B27 in RA but not in PMR in the population of northern Sweden suggests an immunogenetic difference between these two HLA-DR4 associated diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Female
  • HLA Antigens / analysis*
  • HLA-B27 Antigen / analysis
  • HLA-DR4 Antigen / analysis
  • Humans
  • Male
  • Polymyalgia Rheumatica / complications
  • Polymyalgia Rheumatica / genetics
  • Polymyalgia Rheumatica / immunology*
  • Rheumatoid Factor / analysis
  • Sweden
  • Synovitis / complications


  • HLA Antigens
  • HLA-B27 Antigen
  • HLA-DR4 Antigen
  • Rheumatoid Factor