Regulation of glutamic acid decarboxylase mRNA expression in rat brain after sertraline treatment

Eur J Pharmacol. 1996 Sep 26;312(2):183-7. doi: 10.1016/0014-2999(96)00588-2.


We now investigated the effect of chronic treatment with sertraline on glutamic acid decarboxylase mRNA expression in different rat brain areas by means of in situ hybridization. We found a reduced glutamic acid decarboxylase mRNA expression in the prefrontal cortex, accumbens nucleus, olfactory tubercle and reticular nucleus of the thalamus. The involvement of presynaptic modulation of gamma-amino-butyric acid transmission in the anxiolytic effect of sertraline is discussed.

MeSH terms

  • 1-Naphthylamine / analogs & derivatives*
  • 1-Naphthylamine / pharmacology
  • Animals
  • Brain / drug effects*
  • Brain / enzymology
  • Gene Expression Regulation, Enzymologic / drug effects*
  • Glutamate Decarboxylase / genetics*
  • In Situ Hybridization
  • Male
  • RNA, Messenger / genetics*
  • Rats
  • Rats, Sprague-Dawley
  • Serotonin Uptake Inhibitors / pharmacology*
  • Sertraline


  • RNA, Messenger
  • Serotonin Uptake Inhibitors
  • 1-Naphthylamine
  • Glutamate Decarboxylase
  • Sertraline