Regulation of glutamic acid decarboxylase mRNA expression in rat brain after sertraline treatment

L Giardino; M Zanni; C Bettelli; M A Savina; L Calzà

doi:10.1016/0014-2999(96)00588-2

Regulation of glutamic acid decarboxylase mRNA expression in rat brain after sertraline treatment

Eur J Pharmacol. 1996 Sep 26;312(2):183-7. doi: 10.1016/0014-2999(96)00588-2.

Authors

L Giardino¹, M Zanni, C Bettelli, M A Savina, L Calzà

Affiliation

¹ Inst. of Otolaryngol. II, Milano University, Italy. cefisnmo@mbox.vol.it

PMID: 8894594
DOI: 10.1016/0014-2999(96)00588-2

Abstract

We now investigated the effect of chronic treatment with sertraline on glutamic acid decarboxylase mRNA expression in different rat brain areas by means of in situ hybridization. We found a reduced glutamic acid decarboxylase mRNA expression in the prefrontal cortex, accumbens nucleus, olfactory tubercle and reticular nucleus of the thalamus. The involvement of presynaptic modulation of gamma-amino-butyric acid transmission in the anxiolytic effect of sertraline is discussed.

MeSH terms

1-Naphthylamine / analogs & derivatives*
1-Naphthylamine / pharmacology
Animals
Brain / drug effects*
Brain / enzymology
Gene Expression Regulation, Enzymologic / drug effects*
Glutamate Decarboxylase / genetics*
In Situ Hybridization
Male
RNA, Messenger / genetics*
Rats
Rats, Sprague-Dawley
Selective Serotonin Reuptake Inhibitors / pharmacology*
Sertraline

Substances

RNA, Messenger
Serotonin Uptake Inhibitors
1-Naphthylamine
Glutamate Decarboxylase
Sertraline