Spontaneous remission of primary hyperparathyroidism due to hemorrhagic infarction in the parathyroid adenoma

Intern Med. 1996 Aug;35(8):646-9. doi: 10.2169/internalmedicine.35.646.


A 59-year-old man visited Kyoto University Hospital because of general malaise, polyuria, and polydipsia. The diagnosis of primary hyperparathyroidism was made based on hypercalcemia and an elevated circulating PTH level. A nodule was palpable in the left anterior neck. Two weeks later, the serum calcium level was normalized and his symptoms subsided. A temporary expansion, followed by reduction of the tumor size was observed by serial ultrasonography. Histology of the resected tumor showed central necrotic tissue, with some peripherally remaining glandular tissue. We report here a rare case of primary hyperparathyroidism with spontaneous remission due to hemorrhagic infarction in the adenoma.

Publication types

  • Case Reports

MeSH terms

  • Adenoma / complications*
  • Adenoma / diagnostic imaging
  • Adenoma / pathology
  • Alkaline Phosphatase / blood
  • Calcium / blood
  • Hemorrhage / complications*
  • Humans
  • Hyperparathyroidism / blood
  • Hyperparathyroidism / complications*
  • Infarction / complications*
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Parathyroid Hormone / blood
  • Parathyroid Neoplasms / complications*
  • Parathyroid Neoplasms / diagnostic imaging
  • Parathyroid Neoplasms / pathology
  • Remission, Spontaneous
  • Time Factors
  • Ultrasonography


  • Parathyroid Hormone
  • Alkaline Phosphatase
  • Calcium