Immunocytochemical localisation of NK3 receptors in the dorsal vagal complex of rat

Brain Res. 1996 Sep 23;734(1-2):327-31.

Abstract

Using immunohistochemistry, we demonstrate that neurons of the rat dorsal vagal complex (DVC) express NK3 receptors. The density of NK3-immunoreactive neurons depends of the different subnuclei of the nucleus tractus solitarii. The efferent vagal neurons of the dorsal nucleus of the vagus nerve highly express NK3. No NK3-immunoreactivity has been detected in the area postrema. Ultrastructural examination shows that NK3-immunoreactivity is principally present at non synaptic membrane of somatic and dendritic profiles. Therefore, neurokinin B and/or other ligands may act through a process of volume transmission on non synaptic NK3 receptors in the DVC.

MeSH terms

  • Animals
  • Cell Membrane / metabolism
  • Dendrites / metabolism
  • Immunohistochemistry
  • Microscopy, Electron
  • Neurons / metabolism
  • Neurons / ultrastructure
  • Rats
  • Receptors, Neurokinin-3 / metabolism*
  • Solitary Nucleus / metabolism*
  • Solitary Nucleus / physiology*
  • Solitary Nucleus / ultrastructure
  • Tissue Distribution
  • Vagus Nerve / physiology*

Substances

  • Receptors, Neurokinin-3