Fibroblast growth factor receptor 1 in skeletal and heart muscle cells: expression during early avian development and regulation after notochord transplantation

Dev Dyn. 1996 Jul;206(3):310-7. doi: 10.1002/(SICI)1097-0177(199607)206:3<310::AID-AJA8>3.0.CO;2-L.


Basic fibroblast growth factor (bFGF, FGF-2) mediates several biological functions during embryonic development. With regard to skeletal muscle formation, it has been suggested that FGF-2 is involved in the growth and differentiation of myogenic precursor cells. To identify the FGF-responsive cells we studied the expression of FGF receptor type I (FGFR-1) during early embryonic development of the chick. FGFR-1 immunoreactivity is present at all stages examined (embryonic day [E] 2-E5). Expression of FGFR-1 is found in the somite myotome, limb bud muscle cells, eye and tongue muscle cells, and myocardium. Transplantation of an additional notochord into the paraxial mesoderm, which prevents the formation of a myotome, reveals the absence of FGFR-1 immunoreactivity on the operated side. The distinct expression pattern of FGFR-1 in migrating and differentiating muscle cells indicates that in addition to the stimulation of proliferation of myoblasts, FGF-2 exerts other (nonmitogenic) effects on postmitotic myocytes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Division
  • Chick Embryo
  • Coturnix / embryology
  • DNA-Binding Proteins / biosynthesis
  • DNA-Binding Proteins / genetics
  • Embryonic Induction*
  • Gene Expression Regulation, Developmental
  • Heart / embryology
  • In Situ Hybridization
  • Muscle Proteins / biosynthesis*
  • Muscle Proteins / genetics
  • Muscle, Skeletal / embryology
  • Muscle, Skeletal / metabolism*
  • Myocardium / metabolism*
  • Notochord / transplantation*
  • PAX3 Transcription Factor
  • Paired Box Transcription Factors
  • Receptor Protein-Tyrosine Kinases*
  • Receptor, Fibroblast Growth Factor, Type 1
  • Receptors, Fibroblast Growth Factor / biosynthesis*
  • Receptors, Fibroblast Growth Factor / genetics
  • Transcription Factors*


  • DNA-Binding Proteins
  • Muscle Proteins
  • PAX3 Transcription Factor
  • Paired Box Transcription Factors
  • Receptors, Fibroblast Growth Factor
  • Transcription Factors
  • Pax3 protein, mouse
  • Receptor Protein-Tyrosine Kinases
  • Receptor, Fibroblast Growth Factor, Type 1