Phase II trial of etoposide in leiomyosarcoma of the uterus: a Gynecologic Oncology Group study

Gynecol Oncol. 1996 Oct;63(1):120-2. doi: 10.1006/gyno.1996.0289.


Twenty-eight patients with advanced, persistent or recurrent leiomyosarcoma of the uterus not previously exposed to cytotoxic drugs were entered into a study of single-agent intravenous etoposide 100 mg/m2 daily for 3 days every 3 weeks. No complete or partial responses were observed. Thirteen patients demonstrated stable disease, while 15 exhibited increasing disease. Median progression-free interval was 2.1 months, median survival 9.2+ months. The most frequent and severe adverse effects were the result of myelosuppression and manifested primarily as leukopenia and neutropenia. Based on the absence of activity, no further study of intravenous etoposide in leiomyosarcoma of the uterus at the dose and schedule tested is planned.

Publication types

  • Clinical Trial
  • Clinical Trial, Phase II
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Agents, Phytogenic / adverse effects
  • Antineoplastic Agents, Phytogenic / therapeutic use*
  • Etoposide / adverse effects
  • Etoposide / therapeutic use*
  • Female
  • Humans
  • Injections, Intravenous
  • Leiomyosarcoma / drug therapy*
  • Middle Aged
  • Prognosis
  • Survival Analysis
  • Treatment Outcome
  • Uterine Neoplasms / drug therapy*


  • Antineoplastic Agents, Phytogenic
  • Etoposide