Platelet-derived growth factor A and B chains and the alpha and beta receptors in prostatic intraepithelial neoplasia

Prostate. 1996 Nov;29(5):282-6. doi: 10.1002/(SICI)1097-0045(199611)29:5<282::AID-PROS2>3.0.CO;2-C.

Abstract

Background: The objective of this study was to evaluate the expression of platelet-derived growth factor (PDGF A, PDGF B) and their receptors (PDGF alpha, PDGF beta) in prostatic intraepithelial neoplasia (PIN) and adenocarcinoma.

Methods: Peroxidase-antiperoxidase immunoperoxidase labeling was used to detect the extent of antibody labeling in 29 different high grade PIN specimens.

Results: PDGF A and PDGF alpha were uniformly expressed in glandular epithelial and stromal cells, whereas PDGF B was not expressed by either tissue. However, PDGF beta was lightly expressed in a uniform manner by both the glandular epithelial and stromal cells.

Conclusions: The data suggest that an autocrine loop may exist in which the epithelial cells of high-grade PIN express PDGF AA and PDGF alpha to modulate growth of precancerous lesions.

MeSH terms

  • Carcinoma in Situ / chemistry*
  • Humans
  • Image Processing, Computer-Assisted
  • Immunoenzyme Techniques
  • Male
  • Platelet-Derived Growth Factor / analysis*
  • Prostatic Neoplasms / chemistry*
  • Proto-Oncogene Proteins / analysis*
  • Proto-Oncogene Proteins c-sis
  • Receptor, Platelet-Derived Growth Factor alpha
  • Receptor, Platelet-Derived Growth Factor beta
  • Receptors, Platelet-Derived Growth Factor / analysis*

Substances

  • Platelet-Derived Growth Factor
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-sis
  • platelet-derived growth factor A
  • Receptor, Platelet-Derived Growth Factor alpha
  • Receptor, Platelet-Derived Growth Factor beta
  • Receptors, Platelet-Derived Growth Factor