Malignancy-associated pulmonary veno-occlusive disease: report of a case following autologous bone marrow transplantation and review

Bone Marrow Transplant. 1996 Oct;18(4):755-60.


Pulmonary veno-occlusive disease (VOD) is a rare cause of pulmonary hypertension (HTN) which has been described in association with a variety of clinical conditions. Rapidly progressive occlusion of pulmonary veins and venules develops that is usually fatal. Recently, a number of cases have been reported in patients with malignancies. To date, 33 patients have developed pulmonary VOD in association with a malignancy or after chemotherapy and/or radiation therapy. Two-thirds of the cases occurred following allogeneic bone marrow transplantation (BMT). We describe the first case of pulmonary VOD following autologous BMT and review the experience of pulmonary VOD in patients with malignancies.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / adverse effects
  • Bone Marrow Transplantation / adverse effects*
  • Dacarbazine / administration & dosage
  • Dacarbazine / adverse effects
  • Humans
  • Hypertension, Pulmonary / etiology
  • Leukemia, Lymphocytic, Chronic, B-Cell / complications*
  • Leukemia, Lymphocytic, Chronic, B-Cell / therapy*
  • Male
  • Pulmonary Veno-Occlusive Disease / complications
  • Pulmonary Veno-Occlusive Disease / etiology*
  • Pulmonary Veno-Occlusive Disease / pathology
  • Transplantation Conditioning / adverse effects
  • Transplantation, Autologous


  • Antineoplastic Agents
  • Dacarbazine