The epidermal growth factor receptor and its ligands as therapeutic targets in human tumors

Cytokine Growth Factor Rev. 1996 Aug;7(2):133-41. doi: 10.1016/1359-6101(96)00016-0.


The epidermal growth factor receptor (EGFR) is detected on many non-haematopoietic tissues and is frequently overexpressed in human tumors. With its ligand, TGF-alpha, it forms a well-defined autocrine growth loop. Several clinical approaches, using EGFR as a therapeutic target, are being investigated, particularly monoclonal antibodies combined with chemotherapy, and pharmacological inhibition of downstream components of the EGFR signaling pathway.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibodies, Monoclonal / pharmacology
  • ErbB Receptors / chemistry
  • ErbB Receptors / drug effects*
  • ErbB Receptors / metabolism*
  • Gene Expression Regulation, Neoplastic / drug effects
  • Humans
  • Neoplasms / drug therapy*
  • Neoplasms / metabolism
  • Tissue Distribution
  • Transforming Growth Factor alpha / metabolism


  • Antibodies, Monoclonal
  • Transforming Growth Factor alpha
  • ErbB Receptors