Fat-soluble vitamins in cord blood and colostrum in the south of China

Int J Vitam Nutr Res. 1996;66(3):222-6.


Certain diseases have been associated with micronutrient deficiencies in China, and nutritional assessments have become important means of preventing such diseases. In the present study, fat-soluble vitamins including vitamins A, D, E, K, and beta-carotene in the cord blood and colostrum of Chinese subjects in Guilin, China, were assayed and compared with those of Japanese subjects in Osaka, Japan. These vitamins were analyzed by high-performance liquid chromatography. Vitamin A and E levels in the cord blood and colostrum of the Chinese group showed almost the same values as those of the Japanese group. There was also no significant difference in vitamin D level in cord blood between the two groups, while significantly lower levels of beta-carotene and cryptoxanthin, and a higher level of PIVKA-II (protein induced in vitamin K absence) in cord blood were observed in the Chinese group. These findings pointed to a restricted intake of green-yellow vegetables in the Chinese group and an increased risk of hemorrhagic disease in newborn of that group is suggested.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • China
  • Chromatography, High Pressure Liquid
  • Colostrum / chemistry*
  • Diet
  • Fetal Blood / chemistry*
  • Humans
  • Infant, Newborn
  • Japan
  • Reference Values
  • Solubility
  • Vitamin A / analysis
  • Vitamin D / analysis
  • Vitamin E / analysis
  • Vitamin K / analysis
  • Vitamins / blood*
  • beta Carotene / analysis


  • Vitamins
  • beta Carotene
  • Vitamin A
  • Vitamin K
  • Vitamin D
  • Vitamin E