The dilute-lethal (dl) gene attacks a Ca2+ store in the dendritic spine of Purkinje cells in mice

Neurosci Lett. 1996 Sep 13;215(3):169-72. doi: 10.1016/0304-3940(96)12967-0.


The absence of smooth endoplasmic reticulum (SER) in the dendritic spine of Purkinje cells was found in dilute-lethal (dl) mouse cerebella as detected by immunohistochemistry using anti-inositol 1,4,5-triphosphate receptor antibody and electron microscopy. Since SER in the spine has been suggested to play a crucial role for synaptic regulation as an intracellular Ca2+ store (for reviews, see [Miller, R.J., Prog. Neurobiol., 37 (1991) 255-285: Simpson, P.B., Challiss, R.A.J. and Nahorski, S.R., Trends Neurosci., 18 (1995) 299-306]), a neurological defect, characterized by clonic convulsions with opisthotonus and ataxia, in the dilute-lethal mouse with homozygous trait may be attributable to the absence of SER in the dendritic spine of Purkinje cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Cerebellum / ultrastructure*
  • Dendrites / ultrastructure*
  • Genes, Lethal*
  • Mice
  • Mice, Mutant Strains
  • Microscopy, Electron
  • Mutation
  • Purkinje Cells / ultrastructure*


  • Calcium