EM523L, a nonpeptide motilin agonist, stimulates gastric emptying and pancreatic polypeptide secretion

Peptides. 1996;17(6):895-900. doi: 10.1016/0196-9781(96)00143-x.

Abstract

We investigated the efficacy and the mechanism of action of EM523L, a nonpeptide motilin agonist (motilide), on the stimulation of gastric emptying and on the release of gut peptides after ingestion of a solid meat in normal controls (n = 8) and in diabetic patients (n = 8) with signs of neuropathy. A dose of 2 mg EM523L was administered IV over 15 min just after ingestion of a solid meal (200 kcal Gastric emptying was measured by a radionuclide technique. EM523L accelerated gastric emptying and markedly augmented postprandial pancreatic polypeptide (PP) response in both normal control and diabetic patients. This may suggest the mediation of the Vagal-cholinergic pathway to accelerate gastric emptying. The present study offers a promising therapeutic potential of the motilide in gastrointestinal motility disorders like those observed in diabetics mellitus.

MeSH terms

  • Adult
  • Aged
  • Diabetes Mellitus / metabolism*
  • Diabetes Mellitus, Type 1 / metabolism
  • Diabetes Mellitus, Type 2 / metabolism
  • Diabetic Neuropathies / diagnosis
  • Erythromycin / analogs & derivatives*
  • Erythromycin / pharmacology
  • Evaluation Studies as Topic
  • Female
  • Gastric Emptying / drug effects*
  • Gastrointestinal Agents / pharmacology*
  • Humans
  • Male
  • Middle Aged
  • Motilin / agonists*
  • Pancreatic Polypeptide / blood*

Substances

  • Gastrointestinal Agents
  • Motilin
  • Pancreatic Polypeptide
  • Erythromycin
  • EM 523