Large clostridial cytotoxins--a family of glycosyltransferases modifying small GTP-binding proteins

Trends Microbiol. 1996 Oct;4(10):375-82. doi: 10.1016/0966-842X(96)10061-5.


Some Clostridium species produce ABX-type protein cytotoxins of high molecular weight. These toxins constitute the group of large clostridial cytotoxins (LCTs), which have homologous protein sequences, exert glycosyltransferase activity and modify GTP-binding proteins of the Ras-superfamily. These characteristics render the LCTs valuable tools for developmental and cell biologists.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacterial Toxins*
  • Clostridium / chemistry*
  • Cytotoxins*
  • Glycosyltransferases / metabolism*
  • ras Proteins / metabolism*


  • Bacterial Toxins
  • Cytotoxins
  • Glycosyltransferases
  • ras Proteins