EEG and extracelluar K+ in rat brain during pentylenetetrazol seizures and during respiratory arrest

Biomedicine. 1977 Apr;27(3):99-102.

Abstract

The relationship between changes in EEG and the extracellular potassium concentration (K+e) in brain cortex was studied in rats during petylenetetrazol seizures and during respiratory arrest. During seizures an increase of K+e occurred subsequent to the electrical discharges, while during postictal depression of EEG normal levels of K+e were measured. During respiratory arrest K+e rose considerably one minute after flattering of EEG. These findings are against a concept of K+e determining the changes of the EEG pattern. It is hypothetized that during seizures the increased K+e may play an important role in the coupling of neuronal activity to cerebral blood flow and metabolism.

MeSH terms

  • Animals
  • Apnea / metabolism*
  • Apnea / physiopathology*
  • Brain / metabolism*
  • Brain / physiopathology
  • Electroencephalography*
  • Extracellular Space / metabolism
  • Male
  • Pentylenetetrazole
  • Potassium / metabolism*
  • Rats
  • Seizures / chemically induced
  • Seizures / metabolism*
  • Seizures / physiopathology

Substances

  • Potassium
  • Pentylenetetrazole