Wingless Refines Its Own Expression Domain on the Drosophila Wing Margin

Nature. 1996 Nov 7;384(6604):72-4. doi: 10.1038/384072a0.

Abstract

The imaginal discs of Drosophila, which give rise to the adult appendages, are patterned during a period of intense cell proliferation. The specification of differing regions occurs in some cases by subdividing the disc epithelium into lineage compartments. However, in most cases precise boundaries are formed between different cell types without early compartmentalization. One such boundary occurs between the wingless (wg)-expressing cells of the wing margin and the adjacent proneural cells, which give rise to margin sensory bristles. Here we show that this boundary arises in part by a mechanism of 'self-refinement', by which wingless protein (Wg) represses wg expression in adjacent cells. Cells unable to receive the Wg signal do not resolve the boundary between wg-expressing and proneural cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Cell Lineage
  • Dishevelled Proteins
  • Drosophila / embryology
  • Drosophila / genetics*
  • Drosophila Proteins*
  • Embryonic Induction / genetics
  • Embryonic Induction / physiology
  • Gene Expression Regulation, Developmental*
  • Membrane Proteins / genetics
  • Phosphoproteins*
  • Proteins / genetics
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / physiology*
  • Receptors, Notch
  • Signal Transduction
  • Wings, Animal / embryology
  • Wnt1 Protein

Substances

  • Adaptor Proteins, Signal Transducing
  • Dishevelled Proteins
  • Drosophila Proteins
  • Membrane Proteins
  • N protein, Drosophila
  • Phosphoproteins
  • Proteins
  • Proto-Oncogene Proteins
  • Receptors, Notch
  • Wnt1 Protein
  • wg protein, Drosophila