Human papillomavirus genotype as a predictor of persistence and development of high-grade lesions in women with minor cervical abnormalities

Int J Cancer. 1996 Oct 21;69(5):364-8. doi: 10.1002/(SICI)1097-0215(19961021)69:5<364::AID-IJC2>3.0.CO;2-3.


Women referred for colposcopy with mild and moderate dyskaryosis and found to have only minor cervical abnormalities were screened for oncogenic human papilloma virus (HPV) types. The natural development of these abnormalities in 42 HPV-positive women was assessed by cytology and colposcopy at 6-month intervals for up to 2 years. As is the case with cancers and high-grade cervical intra-epithelial neoplasia (CIN), minor cervical abnormalities were frequently found to be associated with HPV16, -18, -31 and -33. Viral persistence and the development of high-grade lesions were found to be closely associated with HPV16; 56% of HPV16 isolates were persistent compared to 7% of other HPV types, and all 4 subsequent CIN 3 lesions were in women with persistent infection. A striking association of persistence with a variant of HPV16 having a base change at nucleotide 350 was observed. Ten of 12 women with this variant had persistent infection compared to only 1 of 16 women infected with the HPV16 prototype.

MeSH terms

  • Adult
  • Aged
  • Base Sequence
  • Cervical Intraepithelial Neoplasia / diagnosis
  • Cervix Uteri / pathology*
  • Cervix Uteri / virology
  • DNA, Viral / chemistry
  • DNA-Binding Proteins*
  • Female
  • Follow-Up Studies
  • Humans
  • Middle Aged
  • Molecular Sequence Data
  • Oncogene Proteins, Viral / genetics
  • Papillomaviridae / genetics*
  • Papillomaviridae / isolation & purification
  • Papillomavirus Infections / pathology*
  • Tumor Virus Infections / pathology*
  • Uterine Cervical Diseases / pathology*
  • Uterine Cervical Diseases / virology


  • DNA, Viral
  • DNA-Binding Proteins
  • E6 protein, Human papillomavirus type 18
  • Oncogene Proteins, Viral