[Clinical pilot study of the myogenic effects of flupirtine in comparison to tetrazepam and placebo]

Arzneimittelforschung. 1996 Mar;46(3):293-8.
[Article in German]


The effects of flupirtine (CAS 56995-20-1, D-9998, Katadolon) on muscle force and related electromyographic (EMG) activity has been assessed in comparison to tetrazepam and placebo in 12 healthy male volunteers after oral single-dose administration and under steady-state conditions. Muscle functions primarily reflecting dynamic daily demands remained unaffected under flupirtine in contrast to tetrazepam, the latter exhibiting the typical signs of increased (co-)innervation which can be interpreted as a compensation of a decrease of muscle force. Under conditions that serve as a model for static-spastic situations, flupirtine showed a decrease, tetrazepam a typical increase in the force parameter. Under the same conditions, a decrease of the EMG-amplitude was observed for flupirtine and, to a lesser extent, for tetrazepam as well. With respect to its muscle relaxing property, flupirtine differs both, quantitatively and qualitatively from tetrazepam, which has shown effects common for benzodiazepines.

Publication types

  • Clinical Trial
  • Comparative Study
  • English Abstract

MeSH terms

  • Adult
  • Aminopyridines / pharmacology*
  • Anti-Anxiety Agents*
  • Benzodiazepines*
  • Benzodiazepinones / pharmacology*
  • Electromyography / drug effects
  • H-Reflex / drug effects
  • Humans
  • Isometric Contraction / drug effects
  • Male
  • Middle Aged
  • Muscle Contraction / drug effects
  • Muscle Relaxants, Central / pharmacology*
  • Muscle, Skeletal / drug effects*
  • Neuroprotective Agents / pharmacology*
  • Pilot Projects


  • Aminopyridines
  • Anti-Anxiety Agents
  • Benzodiazepinones
  • Muscle Relaxants, Central
  • Neuroprotective Agents
  • Benzodiazepines
  • tetrazepam
  • flupirtine