A program for calculating and displaying compatibility matrices as an aid in determining reticulate evolution in molecular sequences

Comput Appl Biosci. 1996 Aug;12(4):291-5. doi: 10.1093/bioinformatics/12.4.291.


Reticulate evolution in molecular sequences is caused by recombination or gene conversion, and may interfere with the reconstruction of evolutionary history. This paper presents a program which calculates compatibility matrices for detecting reticulate evolution. In addition to visual inspection of matrices, they can be analysed statistically for clustering. The method is demonstrated using human and chimpanzee gamma-globin sequences.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Evolution, Molecular*
  • Globins / genetics
  • Humans
  • Monte Carlo Method
  • Pan troglodytes
  • Software*
  • Species Specificity


  • Globins