Human tumor antigens recognized by T cells

Curr Opin Immunol. 1996 Oct;8(5):628-36. doi: 10.1016/s0952-7915(96)80078-1.


The ability of tumor-reactive T cells to mediate in vivo tumor regression has been demonstrated in murine tumor models and by the clinical responses to adoptive immunotherapy with tumor-infiltrating lymphocytes isolated from human melanomas. Investigations carried out in the past several years have resulted in the isolation of a number of the genes encoding antigens recognized by melanoma-reactive T cells. The ability of these products to serve as tumor regression antigens has now begun to be evaluated in clinical vaccine trials.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, Neoplasm* / genetics
  • Cancer Vaccines / pharmacology
  • Clinical Trials as Topic
  • Epitopes / genetics
  • Humans
  • Immune Tolerance
  • Melanoma / genetics
  • Melanoma / immunology
  • Melanoma / therapy
  • Mice
  • Molecular Sequence Data
  • Mutation
  • T-Lymphocytes / immunology*


  • Antigens, Neoplasm
  • Cancer Vaccines
  • Epitopes