Oncogenic proteins as tumor antigens

Curr Opin Immunol. 1996 Oct;8(5):637-42. doi: 10.1016/s0952-7915(96)80079-3.


Human immune responses to oncogenic proteins have been reported and are continuing to be defined. Immunity to nonmutated overexpressed oncoproteins as well as to mutated or unique cancer-specific oncoproteins has been identified. Immune system based treatments targeting oncogenic proteins have shown therapeutic efficacy in animals models and are currently being translated into human clinical trials.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, Neoplasm* / genetics
  • Cancer Vaccines / pharmacology
  • Gene Expression
  • Humans
  • Mutation
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / immunology*
  • Neoplasms / genetics
  • Neoplasms / immunology
  • Neoplasms / therapy
  • Oncogenes
  • Translocation, Genetic


  • Antigens, Neoplasm
  • Cancer Vaccines
  • Neoplasm Proteins