Abstract
Listeria monocytogenes has recently been exploited as a vector for targeting antigens to the immune system. In the past year it has been shown to be particularly effective as a tumor antigen vector. Here we set its potency as a cancer vaccine in the context of the type of immunity induced by this facultative intracellular bacterium.
MeSH terms
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Animals
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Antigen Presentation
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Antigens, Neoplasm / genetics
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Cancer Vaccines / isolation & purification*
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Cytokines / immunology
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Genetic Vectors
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Interferon-gamma / immunology
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Interleukin-1 / immunology
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Interleukin-12 / immunology
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Listeria monocytogenes / genetics
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Listeria monocytogenes / immunology*
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Listeriosis / immunology
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Mice
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T-Lymphocyte Subsets / immunology
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Tumor Necrosis Factor-alpha / immunology
Substances
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Antigens, Neoplasm
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Cancer Vaccines
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Cytokines
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Interleukin-1
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Tumor Necrosis Factor-alpha
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Interleukin-12
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Interferon-gamma