Recombinant Listeria monocytogenes cancer vaccines

Curr Opin Immunol. 1996 Oct;8(5):664-9. doi: 10.1016/s0952-7915(96)80083-5.

Abstract

Listeria monocytogenes has recently been exploited as a vector for targeting antigens to the immune system. In the past year it has been shown to be particularly effective as a tumor antigen vector. Here we set its potency as a cancer vaccine in the context of the type of immunity induced by this facultative intracellular bacterium.

MeSH terms

  • Animals
  • Antigen Presentation
  • Antigens, Neoplasm / genetics
  • Cancer Vaccines / isolation & purification*
  • Cytokines / immunology
  • Genetic Vectors
  • Interferon-gamma / immunology
  • Interleukin-1 / immunology
  • Interleukin-12 / immunology
  • Listeria monocytogenes / genetics
  • Listeria monocytogenes / immunology*
  • Listeriosis / immunology
  • Mice
  • T-Lymphocyte Subsets / immunology
  • Tumor Necrosis Factor-alpha / immunology

Substances

  • Antigens, Neoplasm
  • Cancer Vaccines
  • Cytokines
  • Interleukin-1
  • Tumor Necrosis Factor-alpha
  • Interleukin-12
  • Interferon-gamma