Graft-versus-host effect after allogeneic hematopoietic stem cell transplantation: GVHD and GVL

Curr Opin Immunol. 1996 Oct;8(5):674-80. doi: 10.1016/s0952-7915(96)80085-9.


The development of a graft-versus-host reaction after allogeneic hematopoietic stem cell transplantation is an important determinant of the transplant outcome. A better understanding and improved management of the graft-versus-host reaction should allow improved prevention and treatment of graft-versus-host disease and the development of new strategies to enhance a graft-versus-leukemia effect and to decrease the incidence of leukemic relapse after transplantation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Adhesion Molecules / immunology
  • Cytokines / immunology
  • Disease Models, Animal
  • Graft vs Host Disease / etiology
  • Graft vs Host Disease / immunology*
  • Graft vs Host Disease / prevention & control
  • Graft vs Host Reaction*
  • HLA Antigens / genetics
  • Hematopoietic Stem Cell Transplantation* / adverse effects
  • Humans
  • Immunogenetics
  • Leukemia / immunology
  • Leukemia / therapy
  • T-Lymphocytes / immunology
  • Transplantation, Homologous


  • Cell Adhesion Molecules
  • Cytokines
  • HLA Antigens