The Th1/Th2 paradigm and the allograft response

Curr Opin Immunol. 1996 Oct;8(5):688-93. doi: 10.1016/s0952-7915(96)80087-2.


Although Th1- and Th2-type cytokine profiles have been associated with rejection and tolerance respectively, this paradigm may not be completely accurate. Instead, recent studies suggest that there could be a hierarchy of T-cell growth factors with regard to their ability to block tolerance and induce rejection (rather than a polarized Th1/Th2 demarcation).

Publication types

  • Review

MeSH terms

  • Animals
  • Graft Rejection / immunology
  • Graft Rejection / prevention & control
  • Humans
  • Immune Tolerance
  • Interleukin-2 / immunology
  • Mice
  • Models, Biological
  • Th1 Cells / immunology*
  • Th2 Cells / immunology*
  • Transplantation Immunology*
  • Transplantation, Homologous


  • Interleukin-2