Reversible magnetic resonance imaging lesions in Wilson's disease: clinical-anatomical correlation

J Neuroimaging. 1996 Oct;6(4):246-8. doi: 10.1111/jon199664246.


Described herein is a patient with Wilson's disease who had tremor as a prominent neurological manifestation. T2-weighted magnetic resonance imaging showed abnormal high signal intensities in the bilateral lenticular nuclei, thalami, and red nuclei of the midbrain. Improvement of tremor with copper chelating agents was well correlated with a decrease of the abnormal signals in the thalami and the red nuclei.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Chelating Agents / therapeutic use
  • Copper
  • Corpus Striatum / pathology
  • Female
  • Hepatolenticular Degeneration / drug therapy
  • Hepatolenticular Degeneration / pathology*
  • Hepatolenticular Degeneration / physiopathology
  • Humans
  • Magnetic Resonance Imaging*
  • Red Nucleus / pathology
  • Thalamus / pathology
  • Tremor / drug therapy
  • Tremor / physiopathology


  • Chelating Agents
  • Copper