Gas gangrene is a life-threatening emergency. Most cases are caused by clostridial infections, but nonclostridial causes are being increasingly recognized. Nonclostridial gas gangrene is most often due to polymicrobial organisms. Early diagnosis and therapy are required, since the disease may rapidly progress to fatal toxemia. We report a case of gangrenous, atraumatic, nonclostridial myonecrosis of the arm due to Enterobacter cloacae in a nondiabetic patient with neutropenia.