New model-based indices for maximum expiratory flow-volume curve in patients with chronic obstructive pulmonary disease

Comput Biol Med. 1996 Mar;26(2):123-31. doi: 10.1016/0010-4825(95)00050-x.


New lung function indices based on a lumped parameter model of the maximal expiratory flow-volume (MEFV) curve are presented. The waveforms obtained by the model were compared to the flow-volume curves recorded from normal subjects and from patients with small airways disease, asthma and emphysema. We were able to reproduce the flow-volume curves using the model and calculate new parameters that indicate the degree of lung function impairment and may be applicable to identify mild chronic obstructive pulmonary diseases. Further studies in larger groups of patients are required to better define the true predictive value of the new indices described for the diagnosis of COPD.

MeSH terms

  • Airway Resistance*
  • Case-Control Studies
  • Humans
  • Lung Diseases, Obstructive / diagnosis*
  • Lung Diseases, Obstructive / physiopathology
  • Maximal Expiratory Flow-Volume Curves*
  • Models, Biological
  • Predictive Value of Tests
  • Reference Values
  • Reproducibility of Results
  • Signal Processing, Computer-Assisted