Abstract
A patient receiving sotalol developed recurrent torsades de pointes following the addition of terfenadine (Seldane) to her medical regimen. A 71-year-old woman with a history of atrial fibrillation successfully suppressed with sotalol, 80 mg bid, was started on terfenadine, 60 mg bid. Eight days later, she developed repeated self-terminating episodes of torsades de pointes. Sotalol and terfenadine were discontinued, and no further arrhythmia was observed after 72 hours of temporary pacing was discontinued.
Publication types
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Case Reports
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aged
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Anti-Arrhythmia Agents / administration & dosage
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Anti-Arrhythmia Agents / adverse effects
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Atrial Fibrillation / drug therapy
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Drug Interactions
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Electrocardiography
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Female
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Histamine H1 Antagonists / administration & dosage
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Histamine H1 Antagonists / adverse effects*
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Humans
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Sotalol / administration & dosage
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Sotalol / adverse effects*
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Terfenadine / administration & dosage
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Terfenadine / adverse effects*
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Torsades de Pointes / chemically induced*
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Torsades de Pointes / diagnosis
Substances
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Anti-Arrhythmia Agents
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Histamine H1 Antagonists
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Terfenadine
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Sotalol