Food intake and dosage level, but not tablet vs solution dosage form, affect the absorption of metformin HCl in man

Br J Clin Pharmacol. 1996 Oct;42(4):510-2. doi: 10.1111/j.1365-2125.1996.tb00017.x.


The pharmacokinetics of four single-dose treatments of the metformin administered orally (as the HCl salt) were compared in 24 healthy subjects: 500 mg and 850 mg tablets and 850 mg solution fasting and 850 mg tablet with food. Solution and tablet formulations are bioequivalent. Bioavailability of a 500 mg tablet is 14% greater than that of an 850 mg tablet. Compared with the fasting state, bioavailability is 24% lower, and the peak concentration delayed about 37 min when an 850 mg tablet is administered with food.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Analysis of Variance
  • Dose-Response Relationship, Drug
  • Energy Intake*
  • Humans
  • Hypoglycemic Agents / administration & dosage
  • Hypoglycemic Agents / pharmacokinetics*
  • Intestinal Absorption
  • Male
  • Metformin / administration & dosage
  • Metformin / pharmacokinetics*


  • Hypoglycemic Agents
  • Metformin