Clonal identification of Burkitt's lymphoma arising from lymphocyte-predominant Hodgkin's disease

Br J Haematol. 1996 Nov;95(2):380-2. doi: 10.1046/j.1365-2141.1996.d01-1914.x.


The occurrence of large cell lymphomas subsequent to, or concurrent with, lymphocyte predominant Hodgkin's disease (LPHD) is a well-documented phenomenon. We present a case of Burkitt's lymphoma of the bladder, occurring after the successful treatment of LPHD of a cervical lymph node. To evaluate the clonal relationship of the two tumours, we amplified the complementarity-determining-region 3 of two samples from paraffin-embedded slides, using the polymerase chain reaction (PCR). The sequences of the PCR products showed 96% homology to each other. These results indicate that the malignant clone of Burkitt's lymphoma arose from the corresponding LPHD.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Burkitt Lymphoma / genetics*
  • Gene Rearrangement, B-Lymphocyte, Heavy Chain
  • Hodgkin Disease / drug therapy
  • Hodgkin Disease / genetics*
  • Humans
  • Male
  • Polymerase Chain Reaction
  • Sequence Homology, Nucleic Acid
  • Urinary Bladder Neoplasms / genetics*