Hormonal Regulation of Serum and Endometrial IL-1 Alpha, IL-1 Beta and IL-1ra: IL-1 Endometrial Microenvironment of the Human Embryo at the Apposition Phase Under Physiological and Supraphysiological Steroid Level Conditions

J Reprod Immunol. 1996 Oct;31(3):165-84. doi: 10.1016/0165-0378(96)00982-5.

Abstract

We have investigated serum and intracavitary levels of IL-1 alpha, IL-1 beta and IL-1ra from agonadal women undergoing mock cycles (n = 20) of oocyte donation as a clinical model of controlled hormonal stimulation. Further, we compared the intracavitary IL-1 alpha, IL-1 beta and IL-1ra levels in the microenvironment of the human embryo at the apposition phase, day 5 after progesterone (P) administration using two different clinical models: oocyte donation (n = 20) which provides physiological steroid levels and a higher implantation rate per embryo, and in vitro fertilization (n = 6) with supraphysiological hormonal levels and a lower implantation rate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Embryonic and Fetal Development / immunology*
  • Endometrium / blood supply
  • Endometrium / immunology*
  • Endometrium / metabolism
  • Female
  • Humans
  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1 / biosynthesis*
  • Interleukin-1 / blood*
  • Microcirculation
  • Pregnancy
  • Pregnancy Trimester, First / physiology
  • Progesterone / analysis*
  • Progesterone / pharmacology*
  • Receptors, Interleukin-1 / antagonists & inhibitors*
  • Receptors, Interleukin-1 / drug effects
  • Sialoglycoproteins / biosynthesis*
  • Sialoglycoproteins / blood*
  • Sialoglycoproteins / drug effects

Substances

  • IL1RN protein, human
  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1
  • Receptors, Interleukin-1
  • Sialoglycoproteins
  • Progesterone