Sodium current in periglomerular cells of rat olfactory bulb in vitro

Neuroreport. 1996 Jul 29;7(11):1846-50. doi: 10.1097/00001756-199607290-00032.

Abstract

The capacity of periglomerular cells (PGc) to give fast, Na-dependent action potentials is a crucial and debated issue for the comprehension of how sensory information is processed in the olfactory bulb (OB). Using patchclamp whole cell recording in thin slices of rat OB (P8-P20) we showed that fast sodium conductance is present in all the PGc studied, that this current is sufficiently large to generate action potentials and that action potentials can be evoked in these cells by direct stimulation of the olfactory nerve. A comprehensive kinetic characterization of INa is also presented.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • In Vitro Techniques
  • Interneurons / physiology*
  • Olfactory Bulb / physiology*
  • Patch-Clamp Techniques
  • Rats
  • Rats, Wistar
  • Sodium Channels / physiology*

Substances

  • Sodium Channels