Phospholipases Involved in Lysophosphatidylinositol Metabolism in Rat Brain

J Lipid Mediat Cell Signal. 1996 Sep;14(1-3):33-7. doi: 10.1016/0929-7855(96)01505-2.

Abstract

A phospholipase C activity highly specific for lysophosphoinositide (lysoPI-PLC) has been demonstrated to be present in synaptic plasma membranes of the rat brain. Several lines of evidence suggested that the lysoPI-PLC is an enzyme distinct from known isoforms of phosphoinositide-specific phospholipase C (PI-PLC). On the other hand, the occurrence of a Ca(2+)-independent phospholipase A1 hydrolyzing PI in rat brain was also demonstrated. The lysoPI-PLC hydrolyzed the 2-acyl isomer as well as the 1-acyl isomer of lysoPI. These findings suggest possible pathways for PI metabolism through lysoPI to yield monoacylglycerol (mainly 2-arachidonoyl glycerol) and inositolphosphates in the brain, which are different from the well-characterized PI-PLC pathway.

MeSH terms

  • Animals
  • Brain Chemistry*
  • Lysophospholipids / metabolism*
  • Phospholipases A / metabolism*
  • Phospholipases A1
  • Rats
  • Type C Phospholipases / metabolism*

Substances

  • Lysophospholipids
  • lysophosphatidylinositol
  • Phospholipases A
  • Phospholipases A1
  • Type C Phospholipases