Regulation of the actin cytoskeleton, integrins and cell growth by the Rho family of small GTPases

Cancer Surv. 1996;27:311-22.

Abstract

The Rho family of small GTP binding proteins play a key part in regulating the actin cytoskeleton and cell adhesion through integrin receptors. In addition, these proteins regulate signal transduction pathways essential for normal cell growth. Many of the molecules that regulate Rho have oncogenic activity, suggesting that members of the Rho family may have an important role in tumour formation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actins
  • Animals
  • Cell Adhesion / physiology
  • Cell Division
  • Cytoskeleton / physiology*
  • GTP Phosphohydrolases / physiology*
  • GTP-Binding Proteins / physiology*
  • Humans
  • Integrins / physiology*
  • Neoplasms / etiology
  • Signal Transduction / physiology

Substances

  • Actins
  • Integrins
  • GTP Phosphohydrolases
  • GTP-Binding Proteins