Control of C. elegans larval development by neuronal expression of a TGF-beta homolog

Science. 1996 Nov 22;274(5291):1389-91. doi: 10.1126/science.274.5291.1389.

Abstract

The Caenorhabditis elegans dauer larva is specialized for dispersal without growth and is formed under conditions of overcrowding and limited food. The daf-7 gene, required for transducing environmental cues that support continuous development with plentiful food, encodes a transforming growth factor-beta (TGF-beta) superfamily member. A daf-7 reporter construct is expressed in the ASI chemosensory neurons. Dauer-inducing pheromone inhibits daf-7 expression and promotes dauer formation, whereas food reactivates daf-7 expression and promotes recovery from the dauer state. When the food/pheromone ratio is high, the level of daf-7 mRNA peaks during the L1 larval stage, when commitment to non-dauer development is made.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Animals, Genetically Modified
  • Caenorhabditis elegans / genetics
  • Caenorhabditis elegans / growth & development*
  • Caenorhabditis elegans / metabolism
  • Caenorhabditis elegans Proteins*
  • Genes, Helminth
  • Genes, Reporter
  • Green Fluorescent Proteins
  • Helminth Proteins / chemistry
  • Helminth Proteins / genetics
  • Helminth Proteins / physiology*
  • Humans
  • Larva / growth & development
  • Larva / metabolism
  • Ligands
  • Luminescent Proteins / genetics
  • Molecular Sequence Data
  • Mutation
  • Neurons, Afferent / metabolism*
  • Phenotype
  • Pheromones / pharmacology
  • Temperature
  • Transforming Growth Factor beta / chemistry
  • Transforming Growth Factor beta / genetics
  • Transforming Growth Factor beta / physiology*
  • Transgenes

Substances

  • Caenorhabditis elegans Proteins
  • DAF-7 protein, C elegans
  • Helminth Proteins
  • Ligands
  • Luminescent Proteins
  • Pheromones
  • Transforming Growth Factor beta
  • Green Fluorescent Proteins

Associated data

  • GENBANK/U72883
  • GENBANK/U72884