Purification of a human prostate specific antigen

Invest Urol. 1979 Sep;17(2):159-63.


Rabbit antiserum raised against the crude extract of normal human prostatic tissue contained antibodies to a prostatic tissue-specific antigen as shown by immunoprecipitation techniques. Using this antiserum a prostate antigen was detected in normal, benign hypertrophic, and malignant prostatic tissues, but not in other human tissues. The prostate antigen was purified to homogeneity from prostatic tissues and showed a single protein band on analytical polyacrylamide gel electrophoresis and isoelectric focusing. This report thus presents the first demonstration of the purification of a prostate-specific antigen that does not represent prostatic acid phosphatase.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antigens / isolation & purification*
  • Epitopes
  • Humans
  • Male
  • Prostate / immunology*
  • Prostatic Hyperplasia / immunology
  • Prostatic Neoplasms / immunology


  • Antigens
  • Epitopes