Glucosamine for wound healing

Med Hypotheses. 1996 Oct;47(4):273-5. doi: 10.1016/s0306-9877(96)90066-3.


The rapid production of hyaluronic acid by fibroblasts in the early stages of wound healing may be of crucial importance as hyaluronic acid stimulates the migration and mitosis of mesenchymal and epithelial cells. Increased levels of hyaluronic acid, as observed during fetal wound healing or as achieved by the topical application of hyaluronic acid during wound dressing, are associated with brisker healing and reduced scarring. Glucosamine availability appears to be rate-limiting for hyaluronic acid synthesis. Thus the administration of adequate amounts of glucosamine by mouth during the first few days after surgery or trauma can be expected to enhance hyaluronic acid production in the wound, promoting swifter healing and possibly diminishing complications related to scarring.

MeSH terms

  • Administration, Oral
  • Chemotaxis
  • Cicatrix / prevention & control
  • Epithelial Cells
  • Epithelium / physiology
  • Fibroblasts / physiology
  • Glucosamine / administration & dosage
  • Glucosamine / pharmacology*
  • Glucosamine / therapeutic use*
  • Humans
  • Hyaluronic Acid / biosynthesis
  • Mesoderm / cytology
  • Mesoderm / physiology
  • Mitosis
  • Models, Biological
  • Surgical Procedures, Operative
  • Wound Healing / drug effects
  • Wound Healing / physiology*
  • Wounds and Injuries


  • Hyaluronic Acid
  • Glucosamine